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671. Why Has There Been So Little Progress on Alzheimer’s Disease?

Apr 17, 20261h 1m
Summary

This episode of Freakonomics Radio examines the troubling state of Alzheimer’s disease research, a field that has consumed tens of billions of dollars over several decades without producing a cure or a successful treatment to halt cognitive decline. Host Steven Dubner speaks with investigative journalist Charles Piller and neuroscientist Matthew Shrag to uncover how the scientific community became fixated on the amyloid cascade hypothesis—the theory that beta-amyloid plaques are the primary driver of the disease. The discussion highlights how this hypothesis led researchers down a narrow path, often ignoring other biological drivers like blood vessel health and environmental factors. Shrag, who emerged as a whistleblower, details how he discovered extensive image manipulation in influential research papers. These revelations sparked investigations into companies like Cassava Sciences and prominent academic labs, revealing a pattern of fraudulent data that likely misled the field for years. The episode serves as a sobering look at how academic silos, institutional self-protection, and the immense pressure to secure federal funding can obscure the truth, ultimately delaying real medical progress for the millions of people suffering from Alzheimer’s disease today.

Updated Apr 17, 2026

About This Episode

One possibility: a leading hypothesis pursued by researchers (and funders) was built on science that now appears to be fraudulent. Stephen Dubner speaks with the scientist and the journalist who blew the whistle.

 

  • SOURCES:
    • Charles Piller, investigative journalist for Science, author of Doctored.
    • Matthew Schrag, associate professor of neurology at Vanderbilt University Medical Center.

 

 


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