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The Louis Theroux Podcast

Spotify Studios

S7 EP6: Patrick Radden Keefe on the opioid crisis, criminal career longevity and why access is overrated

Apr 6, 20261h 26m
Summary

In this episode, Louis Theroux sits down with acclaimed investigative journalist and author Patrick Radden Keefe to discuss his process of uncovering secrets, the nature of corruption, and the blurred lines between legal and illicit worlds. The conversation centers on Keefe’s latest book, London Falling, which explores the mysterious death of a teenager living a secret life in London. This story serves as a starting point for a broader discussion on the rise of conspicuous wealth and how specific archetypes, such as the "sigma" male or the "hustle-bro," are amplified by the internet and popular culture. Keefe and Theroux examine why these aspirational, often sociopathic personas resonate with young people, and how institutions—ranging from global art markets to pharmaceutical giants—often reward those who lack traditional empathy. Reflecting on his previous work, such as Empire of Pain, Keefe draws parallels between his investigations into the Sackler family and his broader observations of systemic corruption. They explore how the opioid crisis was fueled by a demand-side shift that originated in doctor-prescribed, FDA-approved drugs. Ultimately, the episode serves as an engaging deep dive into how power, greed, and the erosion of societal norms shape our contemporary world.

Updated May 18, 2026

About This Episode

Joining Louis in the studio today is award-winning writer and investigative journalist, Patrick Radden Keefe. Patrick tells Louis about his investigation into the Sackler family's involvement in the opioid crisis, how professional criminals keep career longevity, and why he thinks access is overrated. Plus he discusses his latest book, London Falling.   Warnings: Strong language and adult themes.     Links/Attachments:     Book: London Falling: A Mysterious Death in a Gilded City and a Family’s Search for Truth, Patrick Radden Keefe (2026)  https://www.panmacmillan.com/authors/patrick-radden-keefe/london-falling/9781035056279     Book: Say Nothing, Patrick Radden Keefe (2019)  https://www.waterstones.com/book/say-nothing/patrick-radden-keefe//9780008159269?sv1=affiliate&sv_campaign_id=259955&awc=3787_1770820651_da19805aca482f3e2f7cdd8da31aca44&utm_source=259955&utm_medium=affiliate&utm_campaign=Genie+Shopping+CSS     Book: Empire of Pain, Patrick Radden Keefe (2022)  https://www.waterstones.com/book/empire-of-pain/patrick-radden-keefe//9781529063103?sv1=affiliate&sv_campaign_id=863943&awc=3787_1770820691_38f3f451369dd9c047c37137a0cb0d42&utm_source=863943&utm_medium=affiliate&utm_campaign=https%3A%2F%2Fwww.octer.co.uk%2F     TV Show: ‘Say Nothing’ (2024) - Hulu  https://www.channel4.com/programmes/say-nothing     Wolf of Wall Street (2013)  https://www.imdb.com/title/tt0993846/     War Dogs (2016)  https://www.imdb.com/title/tt2005151/     Nightcrawler (2014)  https://tv.apple.com/gb/movie/nightcrawler/umc.cmc.1h8fjzqshxpg22pa0bm7iho27?action=play     American Psycho (2000)  https://tv.apple.com/gb/movie/american-psycho/umc.cmc.4k3idfzm0x9j5okdedo2s4l50?action=play     Book: Rogues: True Stories of Grifters, Killers, Rebels and Crooks, Patrick Radden Keefe (2022)  https://www.panmacmillan.com/authors/patrick-radden-keefe/rogues/9781035001767     Glengarry Glen Ross (1992)  https://www.imdb.com/title/tt0104348/     Article: Larry Gagosian Piece, Patrick Radden Keefe (2023)  https://www.newyorker.com/magazine/2023/07/31/larry-gagosian-profile     Book: Hillbilly Elegy, JD Vance, (2017)  https://www.waterstones.com/book/hillbilly-elegy/j-d-vance/9780008220563     Book: Battle Hymn of the Tiger Mother, Amy Chua (2012)  https://www.waterstones.com/book/battle-hymn-of-the-tiger-mother/amy-chua//9781408822074?sv1=affiliate&sv_campaign_id=259955&awc=3787_1770824539_3e1fda19a55aa22e32d76f01e79f390b&utm_source=259955&utm_medium=affiliate&utm_campaign=Genie+Shopping+CSS      Article: The Sinaloa Drug Cartel, Patrick Radden Keefe (2012)  https://archive.nytimes.com/6thfloor.blogs.nytimes.com/2012/06/18/behind-the-cover-story-patrick-radden-keefe-on-the-sinaloa-drug-cartel/    Book: Nazi Billionaires, David De Jong (2023)  https://www.waterstones.com/book/nazi-billionaires/david-de-jong/9780008299798     Book: Some People Need Killing, Patricia Evangelista (2023)  https://www.waterstones.com/book/some-people-need-killing/patricia-evangelista/9781804710081      Book: Killers of the Flower Moon, David Grann (2017)  https://www.waterstones.com/book/killers-of-the-flower-moon-adapted-for-young-adults/david-grann/9781398528482     TV Show: Industry (2020 – present) - BBC  https://www.bbc.co.uk/iplayer/episodes/m000pb89/industry     Podcast: Wind of Change (2020 – 2022) - Crooked Media  https://crooked.com/podcast-series/wind-of-change/     Song: ‘Wind Of Change’, The Scorpions (1990)  https://open.spotify.com/track/3ovjw5HZZv43SxTwApooCM     Song: ‘Piano Man’, Bill Joel (1973)  https://open.spotify.com/track/70C4NyhjD5OZUMzvWZ3njJ     Book: The Journalist and the Murderer, Janet Malcolm (1989)  https://www.londonreviewbookshop.co.uk/stock/the-journalist-and-the-murderer-janet-malcolm     Article: Carl Icahn, Patrick Radden Keefe (2017)  https://www.newyorker.com/magazine/2017/08/28/carl-icahns-failed-raid-on-washington     Credits:  Producer: Millie Chu   Production Manager: Francesca Bassett   Music: Miguel D’Oliveira   Audio Mixer: Tom Guest  Video Mixer: Scott Edwards   Shownotes compiled by Elly Young  Executive Producer: Arron Fellows       A Mindhouse Studios Production for Spotify   www.mindhouse.co.uk    __        Open a Moneybox Cash ISA at https://moneybox.onelink.me/Cqlx/y3xncge  Learn more about your ad choices. Visit podcastchoices.com/adchoices

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