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Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Everyday Wellness™

Ep. 607 How Connective Tissue Disorders Affect Women's Health with Dr. Linda Bluestein | Menopause, Perimenopause, Connective Tissue Health

Jun 17, 20261h 0m
Summary

In this episode, host Cynthia Thurlow welcomes Dr. Linda Bluestein, a board-certified anesthesiologist and integrative pain medicine physician, to discuss the complex world of connective tissue disorders. Dr. Bluestein, who received her own Ehlers-Danlos Syndrome (EDS) diagnosis in her forties, shares her unique journey of pivoting from traditional operating room medicine to specializing in invisible illnesses. The discussion centers on the "trio" often seen together: Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS). Dr. Bluestein explains the physiological mechanisms behind these conditions, clarifying why women are disproportionately affected and how hormones, such as those shifting during perimenopause, play a significant role in symptom expression. The pair explores the spectrum of hypermobility, how it impacts the body beyond simple joint flexibility, and the often-debilitating nature of chronic pain and sympathetic nervous system overdrive. Throughout the episode, Dr. Bluestein offers practical advice for patients navigating mysterious, multi-system symptoms. She emphasizes the importance of patient advocacy, the use of organizational tools to present medical history clearly, and the necessity of finding validating, informed care. Ultimately, the conversation provides a message of hope and empowerment for those living with complex, often misunderstood, chronic illnesses.

Updated Jul 1, 2026

About This Episode

Today, I am thrilled to connect with Dr. Linda Bluestein, a board-certified anesthesiologist and integrative pain medicine physician specializing in Ehlers-Danlos Syndrome, hypermobility spectrum disorders, and related conditions, including POTS, mast cell activation, and chronic pain. In our discussion, we discuss the invisible illness problem and complex medical illnesses, and Dr. Bluestein shares how being diagnosed with EDS in her 40s prompted her to pivot her career to focus on what is missing in medicine regarding those complex illnesses. We explore different types of hypermobility conditions and why women are disproportionately more affected by those conditions than men. We clarify what hypermobility means, the cluster of EDS, POTS, and MCAS, what to do when you have unexplained multi-system symptoms, and how AI can be beneficial. We also examine pain science, hypermobility, sympathetic overdrive, kinesiophobia, anesthesia considerations in connective tissue disorders, and the impact of midlife transitions, HRT, medical gaslighting, nervous system regulation, movement, nutrition, and validation and hope for patients with complex medical illnesses. I am delighted to share this informative conversation with Dr. Linda Bluestein with the Everyday Wellness community, and look forward to having Dr. Bluestein back to explore this topic further. IN THIS EPISODE, YOU WILL LEARN: How patients with complex symptoms often go from specialist to specialist, yet none of them connect the dots. How patients tend to be blamed when treatments fail How POTS diagnosis is often based on heart rate changes, even though it’s not primarily a heart rate condition How dysautonomia affects multiple body systems How, apart from joint flexibility, hypermobility can also involve skin, tissues, organs, and multiple body systems. How EDS, POTS, and MCAS can overlap The value of AI tools for helping patients organize complex symptom histories How sympathetic overdrive and kinesiophobia can worsen chronic pain The impact of medical gaslighting Bio:  Dr. Linda Bluestein Dr. Linda Bluestein is a board-certified anesthesiologist and integrative pain medicine physician who specializes in Ehlers-Danlos Syndromes, hypermobility spectrum disorders, and related conditions, such as POTS, mast cell activation, and chronic pain. She is the founder of Hypermobility MD and the host of the internationally recognized Bendy Bodies Podcast, where she bridges the gap between patients and clinicians by unpacking complex medicine through a pattern-based, whole-person lens. Dr. Bluestein is also an EDS patient herself, bringing both clinical expertise and lived experience to conversations about diagnostic delays, medical gaslighting, and compassionate, effective care. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia’s book, The Menopause Gut. Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Dr. Linda Bluestein Bendy Bodies Podcast Dysautonomia Support Network

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