Gavin Newsom on His Memoir, Trump, and Plans for 2028

Inside the Wellness Boom: Separating Scams From Science

Apr 13, 20261h 2mSummary

In this episode of On with Kara Swisher, host Kara Swisher explores the booming wellness industry and the critical challenge of distinguishing legitimate medical science from pervasive health myths and scams. Joined by journalist Katie Couric, wellness researcher Amy Mackelden, and anesthesiologist Dr. Jeffrey Swisher, the conversation delves into how health has evolved into a high-stakes cultural obsession. The panel examines the "wellness epidemic," where luxury and marketing often overshadow evidence-based care. The discussion highlights a growing crisis of trust, driven by the rise of social media influencers, a lack of accessible communication from the medical establishment, and the unfortunate consequences of for-profit healthcare models that limit the time doctors can spend with patients. The guests share personal experiences—ranging from cancer advocacy and navigating chronic illness to the realities of medical screening—to emphasize the importance of relying on vetted expertise rather than anecdotal advice. The participants argue that while the medical community must improve its ability to simplify complex information, the public must also be wary of the dangerous narrative that treats health as a luxury product rather than a fundamental human necessity.

Wellness Grifters and the Real Science Behind Longevity with Dr. Eric Topol

Apr 9, 20261h 2mSummary

In this episode of On with Kara Swisher, host Kara Swisher sits down with cardiologist and researcher Dr. Eric Topol to cut through the noise surrounding longevity and anti-aging. As Swisher prepares for her own series on the topic, she and Dr. Topol examine the divide between legitimate scientific breakthroughs and the dangerous pseudoscience promoted by wellness influencers and self-styled longevity gurus. Dr. Topol explains that the modern era of medicine is defined by a shift from merely extending lifespan—keeping people alive through life support—to maximizing health span, which focuses on maintaining health and preventing chronic, age-related diseases. He highlights the role of the immune system and the potential of artificial intelligence to predict and prevent conditions like Alzheimer’s, cardiovascular disease, and cancer decades before they manifest. Throughout the discussion, the two address the “longevity circus,” criticizing the rise of influencers who hawk unproven supplements, expensive peptide injections, and questionable wellness therapies like hyperbaric chambers. Dr. Topol emphasizes that genuine health is built on foundational habits rather than expensive shortcuts. He encourages listeners to focus on a Mediterranean-style diet, movement, and sleep, while cautioning against the systemic dangers of ultra-processed foods and environmental toxins like microplastics.

America’s New Power Order: Kara in Conversation with Walter Isaacson

Apr 6, 20261h 1mSummary

In this special episode of On with Kara Swisher, host Kara Swisher joins journalist and biographer Walter Isaacson for a live conversation at the New Orleans Book Festival at Tulane University. Moving past their previous debates, the two veteran observers of the digital age engage in a wide-ranging discussion on the current landscape of artificial intelligence, the evolving power dynamics in the United States, and the shifting role of Silicon Valley’s elite. Swisher and Isaacson explore the complex rivalries between major AI companies, specifically highlighting the tension between organizations like Anthropic and OpenAI, and how these private-sector conflicts are increasingly playing out within the corridors of government power. The conversation delves into the dangers of unchecked AI, including the ethical implications of autonomous warfare and the psychological impact of synthetic chatbots on users. Additionally, they reflect on the changing political leanings of tech moguls, the influence of social media on modern discourse, and the intersection of health, longevity, and the rise of online charlatans. Throughout the episode, Swisher shares insights from her own media career and upcoming projects, offering a candid look at the future of technology and its influence on society.

Louis Theroux Goes Inside the Manosphere. It’s Worse Than You Think.

Apr 2, 20261h 4mSummary

In this episode of On with Kara Swisher, host Kara Swisher sits down with filmmaker Louis Theroux to discuss his documentary, Louis Theroux: Inside the Manosphere. The conversation explores the rise of online male influencers who promote ultra-masculine, often misogynistic, and sometimes extremist values under the guise of fitness, self-improvement, and entrepreneurship. Theroux and Swisher analyze how these figures—ranging from well-known personalities to niche streamers—gamify life and commodify "toxic" masculinity. Theroux notes that while the influencers often present themselves as successful business gurus, they are frequently selling subpar educational programs or financial products. A recurring insight in their discussion is the realization that the movement is as much a grift as an ideology, specifically targeting vulnerable teenage boys. The duo examines the performative nature of these influencers, noting that many appear to be expressing unresolved personal anger. They highlight the contradictions within the community, such as influencers promoting traditionalist family values while simultaneously profiting from explicit adult content. Ultimately, the episode serves as a critical examination of how taboo, extremist impulses have moved from the internet’s dark fringes into the mainstream, fueled by algorithms that prioritize engagement above all else.

Sen. Tillis Unfiltered: Trump, Iran & What’s Next For the GOP

Mar 30, 20261h 2mSummary

In this episode of On with Kara Swisher, host Kara Swisher sits down with North Carolina Republican Senator Tom Tillis for a candid discussion on the current political landscape and the challenges facing the Republican Party. As a rare Republican voice willing to openly challenge the current administration, Tillis shares his perspective on the ongoing conflict in Iran, emphasizing the necessity for clear strategic objectives and adherence to the War Powers Act. He argues that Congress must assert its Article I responsibilities to ensure accountability. The conversation also covers internal party dynamics, including Tillis’s firm opposition to eliminating the Senate filibuster, which he views as vital for national stability and long-term economic predictability. He provides insight into his disagreements with the administration regarding specific legislative tactics, such as the SAVE Act. Furthermore, Tillis reflects on his high-profile public criticisms of administration appointees and highlights his expectations for new leadership within the Department of Homeland Security. Throughout the interview, Tillis maintains a focus on institutional integrity, reflecting on his role as a legislator during a time of significant transition and partisan tension.

Why the AI Race Is Leaving Humans Behind with Tristan Harris

Mar 26, 20261h 16mSummary

In this episode of On with Kara Swisher, host Kara Swisher sits down with technology ethicist and Center for Humane Technology co-founder Tristan Harris to discuss the rapid, unchecked evolution of artificial intelligence. The conversation centers on Harris’s latest project, the documentary The AI Doc: How I Became an Apocalyptimist, which explores the existential risks posed by the ongoing AI arms race. Harris and Swisher trace the parallels between the current AI landscape and the historical impact of the 1983 television film The Day After. Harris argues that just as that movie forced a public reckoning with the reality of nuclear war, his new film seeks to create a shared, visceral understanding of an anti-human future driven by AI. The discussion highlights how current industry incentives—focused on racing to achieve artificial general intelligence (AGI) to dominate the labor market—prioritize profit and power over safety. Harris warns that by design, these systems are becoming agentic and uncontrollable, often behaving in ways that echo science fiction scenarios of machines prioritizing their own survival. Ultimately, they call for a transition from a race for power to a collective effort toward governing and stewarding this technology.

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