GLP-1 Summer School: The Questions We’re Getting Asked All Summer Long

Jun 24, 202655 min

Summary

In this episode of Hump Day Hormones, hosts Dr. Jill Jennings and Courtney Span host a comprehensive "GLP-1 Summer School" to address the most frequent questions they receive in their clinical practice regarding these trending medications. As the popularity of GLP-1 agonists—such as semaglutide and tirzepatide—continues to grow, the hosts aim to cut through the noise and misinformation surrounding their use for weight loss and metabolic health. The discussion explores the mechanism behind GLP-1s, explaining how these peptides mimic natural hormones to regulate insulin, slow gastric emptying, and increase satiety. Beyond simple weight loss, the hosts discuss the broader clinical implications of these medications, including their potential benefits for heart health, chronic kidney disease, fatty liver, and even emerging research into cognitive decline and addictive behaviors. The conversation emphasizes that while GLP-1s are powerful tools, they should be integrated into a foundation of healthy habits, specifically protein intake and resistance training, to prevent the loss of lean muscle mass. The episode concludes with a balanced look at the realities of long-term use, the potential for weight regain upon discontinuation, and the importance of finding a personalized, sustainable approach under professional guidance.

Updated Jun 25, 2026

Health & Wellness Science Society & Culture Women's Health Nutrition Medical Research Weight Loss Hormones

Topics

Safety and Future of Peptide Therapy

About This Episode

This week we're heading back to school, GLP-1 Summer School, to answer the questions we're getting asked every single day in clinic. A few years ago, hardly anyone had heard of medications like Ozempic, Wegovy, Mounjaro, and Zepbound. Now they're everywhere. Some people think they're a miracle. Others think they're dangerous. Most women are simply trying to sort through the noise and understand what is actually true. In this episode, we break down: • How GLP-1 medications actually work in the body • What realistic weight loss looks like with semaglutide and tirzepatide • Why these medications are about much more than weight loss • Whether you'll gain weight back after stopping and how to transition off successfully • The truth about muscle loss, hair loss, and "Ozempic face" • How GLP-1 therapy and hormone replacement therapy may work together • What patients should know about compounded medications • Why retatrutide is generating so much excitement for the future of obesity medicine We also discuss one of the biggest misconceptions surrounding GLP-1 therapy: the idea that the medication is the entire treatment plan. The medication may open the door, but long term success still depends on nutrition, muscle preservation, sleep, stress management, hormone health, and sustainable habits. This conversation is designed to help you understand the science, separate fact from fiction, and make sense of one of the fastest moving areas in medicine today. Share this with the friend who keeps texting you GLP-1 questions. #HumpDayHormones #GLP1 #Semaglutide #Tirzepatide #Ozempic #Wegovy #Zepbound #Mounjaro #MetabolicHealth #WeightLossMedicine #HormoneHealth #WomensHealth

Listen to Hump Day Hormones in Podtastic

For listeners, not advertisers

More Episodes

Why Your Skin Changes During Perimenopause with Special Guest Susan Campbell

Jun 10, 20261h 9m

Summary

In this episode of Hump Day Hormones, host Dr. Jill Jennings sits down with Susan Campbell, founder of the skincare line Phosis, to discuss the often-overlooked skin changes that occur during perimenopause and menopause. As estrogen levels decline, many women experience sudden dryness, sensitivity, and a loss of firmness, symptoms that are frequently misunderstood or mismanaged. The conversation explores the science of aging skin, emphasizing the crucial role of the skin barrier. Campbell explains how traditional anti-aging products often use harsh, aggressive ingredients that can further damage a weakened barrier, essentially adding fuel to the fire. Instead, she advocates for a restorative approach that prioritizes healthy barrier function over temporary fixes. Beyond the science, Campbell shares her personal journey as an entrepreneur, highlighting the challenges of developing clean, plant-based products specifically for menopausal skin. She underscores the importance of clinical testing, distinguishing between consumer perception studies and rigorous, IRB-reviewed clinical trials. By focusing on the structural needs of the skin—such as the replenishment of ceramides—this episode provides listeners with a foundational understanding of how to care for their skin during this significant hormonal transition, encouraging women to embrace their changing needs with evidence-based solutions.

Related Podcasts

The Daily

The New York Times

Stuff You Should Know

iHeartPodcasts

The Diary Of A CEO with Steven Bartlett

DOAC

The Joe Rogan Experience

Joe Rogan

99% Invisible

Roman Mars

The Rest Is Politics

Goalhanger

All podcast names and trademarks are the property of their respective owners. Podcasts listed on Podtastic are publicly available shows distributed via RSS. Podtastic does not endorse nor is endorsed by any podcast or podcast creator listed in this directory.